NEW MATERIAL:A compound expressed by formula I {R1 us H, halogen, alkyl, NH2 or alkoxy; R3 is H, halogen, alkoxy, OH, alkyl, NH2, etc.; R3 is NR4R5 [R4 is H, benzoyl, etc.; R5 is formula II (R10 is halogen, alkyl, OH, CN, NO2, etc.; (m) is 3-0), alkanoyl, etc.] or formula III (R11 is H or alkyl; R12 is cycloalkyl or phenyl); W is (CH2)p, or CH=CH-(CH2)q ((p) is 3-5; (q) is 1-3)}
EXAMPLE: 4-Methylamino-1-[4-(3,5-dichlorobenzoylamino)benzoyl]-1,2,3,4- tetrahydroquinoline.
USE: Useful as vasopressin antagonistic agents, vasodilators, hypotensive agents, water diuretic agents, blood platelet agglutination inhibitors, etc.
PREPARATION: For example, a benzoheterocyclic compound expressed by formula IV is made to react with a carboxylic acid expressed by formula V according to conventional reaction for forming amide bonds to afford the objective compound expressed by formula I.
MIYAMOTO HISASHI
KONDO KAZUMI
YAMASHITA HIROSHI
NAKAYA KENJI
KOMATSU HAJIME
TANAKA MICHINORI
TAKARA SHINYA
TOMINAGA MICHIAKI
YABUUCHI YOICHI
Next Patent: PHENOXYACETIC ACID DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME