NEW MATERIAL:The benzoic acid derivative of formula I (R1 and R2 are H, lower or medium alkyl or together form a 5W6-membered cycloalkyl, at least one of R1 and R2 is not H; R3 is OH, lower alkoxy or -NR4R5; R4 and R5 are H or lower alyl; X is group of formula II, formula III, -N=N-, etc.; R6 and R7 are H or lower alkyl).
USE: It has the activity to morphologically and functionally promote the differentiation of cancer cell, especially leukemia cell, and is useful as a drug.
PREPARATION: The objective compound of formula I can be prepared by condensing the compound of formula I wherein X is -CO-C(R6)=CH- with corresponding acetophenone derivative and a terephthalaldehydic acid ester or its derivative in the presence of a base. As an alternative method, the objective compound wherein the group X is formula III is produced by oxidizing a compound wherein the corresponding group X is C(R6)=C(R7) with an epoxidizing agent.
| JPS5528911A | 1980-02-29 | |||
| JPS58164603A | 1983-09-29 | |||
| JPS58128340A | 1983-07-30 |
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