NEW MATERIAL:The compound of formula I [R1WR5 are H, alkyl or adjacent two groups together form a 5- or 6-membered cycloalkyl; R1WR5 are not H at the same time; R6 is H, alkoxy or NR7R8 (R7 and R8 are H or alkyl); X is group of formula II W formula VI, N=N, etc.].
USE: A differentiation inducing agent for cancer cell, especially leukemia cell.
PREPARATION: A compound of formula I wherein X is group of formula II can be prepared by reacting the corresponding acetophenone derivative with a terephthalaldehydric acid ester or its derivative in the presence of a base. The product can be converted to another compound of formula I wherein X is group of formula III by oxidizing with an epoxidizing agent. A compound of formula I wherein X is N=N is obtained by the condensation of the corresponding aniline derivative with p-nitrosobenzoic acid ester.
| JPS5528911A | 1980-02-29 | |||
| JPS58164603A | 1983-09-29 | |||
| JPS58128340A | 1983-07-30 | |||
| JPS6122047A | 1986-01-30 |