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Title:
BENZOQUINONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS58174342
Kind Code:
A
Abstract:

NEW MATERIAL:The benzoqunone derivative of formula I (A is CO or CH2; one of R1 and R2 is H and the other is methyl; m is 0W21).

USE: It has activities to inhibit the protocollagen.proline hydroxylase and suppress the collagen biosynthesis. It is useful as an agent for suppressing the fibrinosis of animal tissue, for the prevention and remedy of organofibrosis of animals especially mammals such as rabbit, rat, dog, etc. For example, the compound is useful as a remedy for pulmonary fibrosis, hepatocirrhosis, nephrosclerosis, arteriosclerosis, scleroderma, myelofibrosis, chronic arthritis, etc.

PROCESS: The compound of formula I wherein A is CH2 can be prepared e.g. by reaction the quinone of formula II or the (protected) hydroquinone of formula III(R3, R4 and R5 are H or acyl) with a metal hydride, e.g. lithium aluminum hydride, etc. in an organic solvent such as ether, and oxidizing the resultant compound with an oxidizing agent such as silver oxide.


Inventors:
OKAZAKI NAOYOSHI
WATANABE MASAZUMI
IMADA ISUKE
Application Number:
JP5747382A
Publication Date:
October 13, 1983
Filing Date:
April 06, 1982
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K31/045; A61K31/12; A61K31/19; A61P7/02; C07C45/00; C07C50/28; C07C67/00; (IPC1-7): A61K31/045; A61K31/12; A61K31/19; C07C50/28
Attorney, Agent or Firm:
Hiroshi Iwata



 
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