Title:
モノアシルグリセロールリパーゼ阻害剤として有用なベンゾオキサジン誘導体
Document Type and Number:
Japanese Patent JP7403453
Kind Code:
B2
Abstract:
The invention provides new heterocyclic compounds having the general formula (I)wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Inventors:
Bell, Charles
Benz, Jörg
Greetter, uwe
Hornsperger, Benoit
Kochel, Burent
Kuhn, Bernd
Richter, Hans
Satoshi Tsuchiya
Benz, Jörg
Greetter, uwe
Hornsperger, Benoit
Kochel, Burent
Kuhn, Bernd
Richter, Hans
Satoshi Tsuchiya
Application Number:
JP2020531586A
Publication Date:
December 22, 2023
Filing Date:
December 13, 2018
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D413/06; A61K31/538; A61P25/00; A61P25/04; A61P25/06; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2012524810A | ||||
| JP2013527227A | ||||
| JP2021504467A |
Foreign References:
| WO2016158956A1 | ||||
| WO2017170830A1 |
Other References:
Huayou Chen et al.,Structural and energetic insights into the selective interactions of monoacylglycerol lipase with its natural substrate and small-molecule inhibitors,Medicinal Chemistry Research,2014年,23巻,2391-2404頁
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN ,2017年09月21日,RN 2129025-04-1 REGISTRY N-Cyclohexyl-4-[(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-6-yl)carbonyl]-1-piperazinecarboxamide Supplier: Aurora Fine Chemicals
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN ,2016年05月02日,RN 1901859-22-0 REGISTRY 6-[[4-(Phenylmethyl)-1-piperazinyl]carbonyl]-2H-1,4-benzoxazin-3-one Supplier: Aurora Fine Chemicals
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年08月19日,RN 1320255-10-4 REGISTRY 1-[(3,4-Dihydro-3-oxo-2H-1,4-benzoxazin-6-yl)carbonyl]-N-[(3-fluoro-4-methylphenyl)methyl]-4-piperidinecarboxamide Supplier:Aurora Fine Chemicals
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2007年04月20日,RN 931085-56-2 REGISTRY 6-[[4-(Phenylmethyl)-1-piperidinyl]carbonyl]-2H-1,4-benzoxazin-3-one Supplier: Enamine
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN ,2017年09月21日,RN 2129025-04-1 REGISTRY N-Cyclohexyl-4-[(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-6-yl)carbonyl]-1-piperazinecarboxamide Supplier: Aurora Fine Chemicals
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN ,2016年05月02日,RN 1901859-22-0 REGISTRY 6-[[4-(Phenylmethyl)-1-piperazinyl]carbonyl]-2H-1,4-benzoxazin-3-one Supplier: Aurora Fine Chemicals
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2011年08月19日,RN 1320255-10-4 REGISTRY 1-[(3,4-Dihydro-3-oxo-2H-1,4-benzoxazin-6-yl)carbonyl]-N-[(3-fluoro-4-methylphenyl)methyl]-4-piperidinecarboxamide Supplier:Aurora Fine Chemicals
DATABASE REGISTRY [online] CHEMICAL ABSTRACT SERVICE, US; Retrieved from STN,2007年04月20日,RN 931085-56-2 REGISTRY 6-[[4-(Phenylmethyl)-1-piperidinyl]carbonyl]-2H-1,4-benzoxazin-3-one Supplier: Enamine
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni
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