Title:
ベンゾイルピリダジン
Document Type and Number:
Japanese Patent JP4354652
Kind Code:
B2
Abstract:
A group of compounds of, the preparation of, and the methods of use of benzoylpyridazine derivatives and the physiologically acceptable salts and solvates thereof, which have valuable pharmacological properties while well tolerated. They selectively inhibit phosphodiesterase IV with an intracellular increase in the CAMP level, and have an inhibitory effect on the formation of tumor necrosis factor.
Inventors:
Jonas, Rohous
Wolf, Michael
Kruksen, Franz-Wenner
Wolf, Michael
Kruksen, Franz-Wenner
Application Number:
JP2000579590A
Publication Date:
October 28, 2009
Filing Date:
October 23, 1999
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D237/04; A61K31/50; A61K31/501; A61P1/04; A61P3/10; A61P9/10; A61P11/06; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D273/04; C07D401/12
Domestic Patent References:
| JP8291145A | ||||
| JP9124611A | ||||
| JP7508987A |
Foreign References:
| WO1998006704A1 |
Other References:
山川浩司他,新版メディシナルケミストリー,日本,講談社,1987年 4月10日,p.46-47
COMBS, D.W. et al.,J. Med. Chem.,1995年,Vol.38/No.25,p.4878-4879
COMBS, D.W. et al.,J. Med. Chem.,1995年,Vol.38/No.25,p.4878-4879
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Masaaki Ogata
Ohta Kengaku
Ishibashi Masayuki
Masaaki Ogata
Ohta Kengaku