Title:
【発明の名称】ベンジルピペラジニル-およびベンジルピペリジニルエタノン誘導体、その調製、およびドーパミンD4受容体アンタゴニストとしてのその使用
Document Type and Number:
Japanese Patent JP2002504549
Kind Code:
A
Abstract:
Disclosed are compounds of formula (I) or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH; R1, R2 and R3 represents hydrogen, halogen, hydroxy, alkoxy, alkyl, trifluoromethyl or trifluoromethoxy; R4 and R4' represent hydrogen, alkyl or form a ring with the atom to which they are attached; R5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R6 represents hydrogen or alkyl; or R5 and R6 form a ring together with the atoms to which they are attached; and R7, R8, R9, R10 and R11 represent hydrogen or alkyl, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents. Also encompassed within the scope of the invention are intermediates of formulae (VII-a) and (VII-b) wherein X represents oxygen, or sulfur, or CH2, m is zero or an integer of from 1-4, and L is a leaving group.
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Inventors:
Cover, Renata X.
Terjanian, Silva
Tran, Jennifer
Turkaf, Andrew
Terjanian, Silva
Tran, Jennifer
Turkaf, Andrew
Application Number:
JP2000533426A
Publication Date:
February 12, 2002
Filing Date:
February 26, 1999
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
A61K31/4427; A61K31/445; A61K31/4523; A61K31/454; A61K31/4709; A61K31/495; A61K31/496; A61K31/5375; A61K31/538; A61K31/5415; A61K31/55; A61P25/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D209/08; C07D209/54; C07D209/96; C07D211/34; C07D215/08; C07D221/20; C07D223/16; C07D225/06; C07D265/36; C07D267/22; C07D279/16; C07D295/15; C07D295/14; C07D401/06; C07D413/06; C07D417/06; (IPC1-7): C07D209/08; A61K31/445; A61K31/4523; A61K31/454; A61K31/4709; A61K31/495; A61K31/496; A61K31/538; A61K31/5415; A61K31/55; A61P25/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D209/96; C07D211/34; C07D215/08; C07D221/20; C07D223/16; C07D225/06; C07D265/36; C07D267/22; C07D279/16; C07D295/14; C07D401/06; C07D413/06; C07D417/06
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)