Title:
ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用
Document Type and Number:
Japanese Patent JP2004516286
Kind Code:
A
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:or a pharmaceutically acceptable salt thereof, e.g. where R3 is -CH2NH2, -CH2CH2NH2, or -CH2NHC(O)OC(CH3)3.
Inventors:
Sernitsk, Harold Gee
Barrow, The Ames Sea
Nan Therme, Filip Jie
Williams, Peter Day
Stouffer, Kenneth J.A.
Sanderson, Philip Y
Little, kenneth yee
Moriset, Machine M
Whiscount, Katherine M
Trang, Lekhan Oh
Lyle, Terry A
Stars, Donett Day
Barrow, The Ames Sea
Nan Therme, Filip Jie
Williams, Peter Day
Stouffer, Kenneth J.A.
Sanderson, Philip Y
Little, kenneth yee
Moriset, Machine M
Whiscount, Katherine M
Trang, Lekhan Oh
Lyle, Terry A
Stars, Donett Day
Application Number:
JP2002551552A
Publication Date:
June 03, 2004
Filing Date:
December 14, 2001
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
A61K31/165; A61K31/397; A61K31/401; A61K31/4025; A61K31/4439; A61K31/454; A61P7/02; A61P9/00; A61P9/10; C07C237/22; C07D205/04; C07D207/08; C07D207/16; C07D401/06; C07D403/12; C07K5/06; C07K5/062; C07K5/065; C07K5/078; A61K38/00; (IPC1-7): C07C237/22; A61K31/165; A61K31/397; A61K31/401; A61K31/4025; A61K31/4439; A61K31/454; A61P7/02; A61P9/00; A61P9/10; C07D205/04; C07D207/08; C07D401/06; C07D403/12
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura