Title:
ベンゼン環上に二置換基を有するβ-ベンジルオキシアスパラギン酸誘導体
Document Type and Number:
Japanese Patent JP4008446
Kind Code:
B2
Abstract:
The present invention provides a ²-benzyloxyaspartic acid derivative having two substituents on its benzene ring, wherein the derivative has L-glutamate uptake inhibitory effect. More specifically, the present invention provides a compound of Formula (1) having an inhibitory effect against the glutamate uptake activity of L-glutamate transporters (wherein R 1 represents an optionally substituted aromatic group, and substituent R 2 represents a group selected from an optionally substituted linear or branched C 1 -C 30 aliphatic group whose chain may contain nitrogen or oxygen, and an optionally substituted aromatic group) or a salt thereof, and a method for obtaining the above compound, as well as a method for purifying or detecting L-glutamate transporters using the above compound.
Inventors:
Keiko Shimamoto
Application Number:
JP2004377557A
Publication Date:
November 14, 2007
Filing Date:
December 27, 2004
Export Citation:
Assignee:
Suntory Limited
International Classes:
C07C237/12; C07C233/75; C07K1/22; G01N21/64; G01N21/78; G01N30/88; G01N33/53; G01N33/68
Domestic Patent References:
| JP10130215A |
Foreign References:
| WO2005090268A1 | ||||
| WO2003000698A1 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto