Title:
BETA-LACTAM ANTIBACTERIALS, MANUFACTURE AND COMPOSITION
Document Type and Number:
Japanese Patent JPS58183692
Kind Code:
A
Abstract:
A compound of formula (1) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: (I) wherein R1 is phenyl, substituted phenyl or a 5- or 6-membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C1-6 alkoxy; X represents; +TR wherein RY is methyl or acetyl; R2 and R3 may be the same or different and each is hydrogen, an aryl group, a heterocyclyl group or a C1-6 alkyl group optionally substituted by an aryl group or a heterocyclyl group; and R4 is hydrogen, a C1-6 alkylcarbonyl group, an aryl group, a heterocyclyl group, a C1-6 alkyl group optionally substituted by an aryl group or a heterocyclyl group; R5 represents, hydrogen, methoxy or -NHCHO; and Y is: wherein Y1 is oxygen, sulphur or -CH2- and Z represents hydrogen, halogen or an organic group such as C1-4 alkoxy, -CH2Q or -CH=CH-Q wherein Q represents hydrogen, halogen, hydroxy, mercepto, cyano, carboxy, carbamoyloxy carboxylic ester, C1-4 alkyloxy, acyloxy, aryl, a heterocyclyl group bonded via carbon, a heterocyclylthio group or a nitrogen containing heterocyclic group bonded via nitrogen.
Inventors:
ANDORIYUU UIRIAMU TEIRAA
RICHIYAADO TOOMASU KUTSUKU
RICHIYAADO TOOMASU KUTSUKU
Application Number:
JP5498983A
Publication Date:
October 26, 1983
Filing Date:
March 30, 1983
Export Citation:
Assignee:
BEECHAM GROUP LTD
International Classes:
C07D499/08; A61K31/43; A61P31/04; C07D231/20; C07D231/26; C07D499/00; C07D499/12; C07D499/64; C07D499/68; C07D499/70; C07D501/20; (IPC1-7): A61K31/43; C07D499/64; C07D499/68; C07D499/70
Attorney, Agent or Firm:
Akizawa Masamitsu
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