BETA-LACTAM ANTIBIOTIC PA-31088-II AND ITS PREPARATION

Title:

BETA-LACTAM ANTIBIOTIC PA-31088-II AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS57102890

Kind Code:

A

Abstract:

NEW MATERIAL:An antibiotic substance PA-31088-II, chemical name: (5R,6R)- 3-[(E)-2-acetamidoethenylsulfinyl]-6-[(S)-1-hydroxyethyl]-7-oxo-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid of the formula and a salt thereof.

USE: An antimicrobial agent and an inhibitor against β-lactamases.

PROCESS: Streptomyces tokunonensis PA-31088 (FERM-P No.4843) or Streptomyces argenteolus PA-39504 (FERM-P No.5265) is cultivated in a liquid cluture medium under aerobic conditions, and the aimed substance is then separated by the filtration, various ion exchange resins, etc. and purified to give the compound of the formula.

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Inventors:

TANAKA KENTAROU
KONDOU EIJI
TSUJI NAOKI
MATSUMOTO KOUICHI
SHIYOUJI JIYUNICHI

Application Number:

JP18079980A

Publication Date:

June 26, 1982

Filing Date:

December 19, 1980

Export Citation:

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Assignee:

SHIONOGI SEIYAKU KK

International Classes:

C07D477/00; A61K31/397; A61K31/40; A61P31/04; C07D487/04; C12P17/18; C12R1/465; (IPC1-7): A61K31/40; C07D487/04; C12P17/18

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