Title:
BIARYL COMPOUND, METHOD FOR PRODUCING THE SAME AND AGENT
Document Type and Number:
Japanese Patent JP2003055326
Kind Code:
A
Abstract:
To provide a medicine having activities for increasing a low-density lipoprotein (LDL) receptor, and useful as an agent for reducing lipid in blood or the like.
The compound represented by the formula [wherein, A-ring and B-ring are each a 5- or 6-membered aromatic ring which may be substituted; R1 and R2 are each a hydrogen atom, a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X1, X2, X3 and X4 are each a bond or a divalent hydrocarbon group which may be substituted; Y is -NR3-CO-, -CO-NR3-, -NR3-SO2-, -SO2-NR3-, -NR3-CH2- (R3 is a hydrogen atom, a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted) or the like; Z is -CO-NH-, -CS-NH, -CO- or -SO2-; Ar is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted].
Inventors:
KORI MASAKI
ISHIKAWA EIICHIRO
NAKADA MIKIYO
KOBAYASHI MAKOTO
Application Number:
JP2002004422A
Publication Date:
February 26, 2003
Filing Date:
January 11, 2002
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07D333/20; A61K31/166; A61K31/17; A61K31/18; A61K31/341; A61K31/381; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/443; A61K31/4436; A61K31/444; A61K31/455; A61K31/506; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P5/50; A61P7/02; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P43/00; C07C231/02; C07C233/78; C07C235/50; C07C273/18; C07C275/30; C07C275/34; C07C275/40; C07C303/38; C07C311/18; C07D213/40; C07D213/42; C07D213/75; C07D213/82; C07D307/52; C07D401/12; C07D405/12; C07D409/12; (IPC1-7): C07C233/78; A61K31/166; A61K31/17; A61K31/18; A61K31/341; A61K31/381; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/443; A61K31/4436; A61K31/444; A61K31/455; A61K31/506; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P5/50; A61P7/02; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P43/00; C07C231/02; C07C235/50; C07C273/18; C07C275/30; C07C275/34; C07C275/40; C07C303/38; C07C311/18; C07D213/40; C07D213/42; C07D213/75; C07D213/82; C07D307/52; C07D333/20; C07D401/12; C07D405/12; C07D409/12
Attorney, Agent or Firm:
Sekiguchi Yo (1 person outside)
