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Title:
BICYCLIC COMPOUND AS EXCITATORY AMINO ACID RECEPTOR ANTAGONIST
Document Type and Number:
Japanese Patent JPH07149724
Kind Code:
A
Abstract:

PURPOSE: To obtain a novel bicyclic compound useful as an antagonist against excitatory amino acid receptors and in the treatment of neurological disorders.

CONSTITUTION: This bicyclic compound is a compound represented by the formula (wherein W is O or S; R1 is CO2R2, PO3H2, tetrazol-5-yl or thiotetrazolyl; R2 is H, a 1-6C alkyl, a substituted alkyl, a cycloalkyl or an arylalkyl; R3 is H, a 1-10C alkyl, an arylalkyl, an alkoxycarbonyl, an aryloxycarbonyl, an arylalkoxycarbonyl, or an acyl; (n) is 0-2; (m) and (p) are each 0 or 1; and provided that, when R1 is thiotetrazolyl, (m) is 0 or the sum of (n), (m) and (p) is at least 1 or when (m) is 1 and R1 is CO2H, (p) is 1) or a pharmaceutically acceptable salt thereof, e.g. (1SR, 2SR, 5RS, 8SR)-3-aza-8-{[1(2)H-tetrazol-5- yl]methyl}bicyclo[3,3,0]octane-2-carboxylic acid.


Inventors:
JIEIMUZU AREN MON
Application Number:
JP24617194A
Publication Date:
June 13, 1995
Filing Date:
October 12, 1994
Export Citation:
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Assignee:
LILLY CO ELI
International Classes:
A61K31/40; A61K31/403; A61K31/41; A61K31/675; A61P9/10; A61P25/00; A61P25/04; A61P25/06; A61P25/20; C07D209/52; C07D209/94; C07D403/06; C07D403/12; C07D513/14; C07F9/572; (IPC1-7): C07D209/52; A61K31/40; A61K31/41; A61K31/675; C07D403/12; C07D513/14; C07F9/572
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)