Title:
二環式化合物、その組成物および医薬用途
Document Type and Number:
Japanese Patent JP6854776
Kind Code:
B2
Abstract:
Substituted bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts and pharmaceutical compositions containing them are disclosed, as well as processes for preparing and using the compounds. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of retinoic acid-related orphan receptor gamma (RORy). Representative conditions include inflammatory and/or autoimmune disorder, rheumatoid arthritis, psoriasis, psoriatic arthritis, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, COPD, cancer, cell proliferation, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, systemic lupus, crythematosus or other disorders.
Inventors:
Mukpadiya, Parser
Munaut, Yogeshi
Shaiff, Nadim
Kukerney, Bhima Shanker A.
Mouktiar, Qasim
Munaut, Yogeshi
Shaiff, Nadim
Kukerney, Bhima Shanker A.
Mouktiar, Qasim
Application Number:
JP2017554656A
Publication Date:
April 07, 2021
Filing Date:
January 08, 2016
Export Citation:
Assignee:
Impetis Bioscience Limited
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4545; A61K31/497; A61K31/4985; A61K31/506; A61K31/519; A61K31/5377; A61K45/00; A61P1/02; A61P1/04; A61P1/12; A61P3/10; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/06; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P37/02; A61P37/06; A61P37/08; A61P39/02; A61P43/00; C07D471/08; C07D487/04
Domestic Patent References:
| JP2014509316A | ||||
| JP2013530210A |
Foreign References:
| WO2014028589A2 | ||||
| WO2014028591A2 | ||||
| WO2014028597A2 |
Attorney, Agent or Firm:
Maeda/Suzuki International Patent Corporation