Title:
二環性化合物、その製造法および用途
Document Type and Number:
Japanese Patent JP4358851
Kind Code:
B2
Abstract:
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is (S)-8-[4-(2-butoxyethoxy)phenyl]-1-isobutyl-N-(4-{[(1-propyl-1H-imidazol-5-yl)-methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide, or a salt thereof. The compound is used for the treatment and prophylaxis of a disease selected from the group consisting of autoimmune diseases, diabetic diseases, chronic pain, inflammatory diseases, arteriosclerosis diseases, chronic rheumatoid arthritis, and restenosis.
Inventors:
Mitsuru Shiraishi
Masanori Baba
Aikawa Katsuji
Naoyuki Kanzaki
Masaki Seto
Yuji Iizawa
Masanori Baba
Aikawa Katsuji
Naoyuki Kanzaki
Masaki Seto
Yuji Iizawa
Application Number:
JP2006355701A
Publication Date:
November 04, 2009
Filing Date:
December 28, 2006
Export Citation:
Assignee:
Takeda GmbH
International Classes:
C07D403/12; A61K31/351; A61K31/395; A61K31/4178; A61K31/4196; A61K31/427; A61K31/472; A61K31/4725; A61K31/496; A61K31/513; A61K31/536; A61K31/5513; A61K31/7072; A61K31/7076; A61K31/708; A61K45/00; A61P7/00; A61P9/10; A61P13/12; A61P19/02; A61P29/00; A61P31/18; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D225/06; C07D313/20; C07D403/14; C07D405/12; C07D407/12
Domestic Patent References:
| JP2003335776A | ||||
| JP2000128782A | ||||
| JP2000128842A |
Attorney, Agent or Firm:
Shinki Global IP Patent Corporation