Title:
BICYCLIC CYCLIC AMINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3268098
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new antimicrobial compound useful as a medicine, an animal medicine, an aquatic medicine, an antimicrobial preservative, etc.
CONSTITUTION: A compound of formula I [X1 and X2 are halogen; R1 is H, OH, thiol, 1-6C alkyl, etc.; R2 is bicyclic heterocyclic substituent group of formula II (R3 and R4 are H, 1-4C alkyl, etc.; Y is 0, S, etc.; (m) and (n) are 2 or 3; (p), (q) and (r) are 0-3 and p+q+r is 0-3); A is N or group of formula III (X3 is H, halogen, cyano, 1-6C alkyl, etc.); R is H, phenyl, acetoxymethyl, choline, etc.] such as 5-amino-7-[(S,S)-2,8-diazabicyclo[4,3,0]nonan-8-yl]-6,8- difluoro-1-[(1R,2S)-2fluorocyclopropyl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. The compound of formula I is produced from a compound of formula IV as a starting substance.
Inventors:
Makoto Takemura
Youichi Kimura
Norikazu Matsuhashi
Youichi Kimura
Norikazu Matsuhashi
Application Number:
JP32301193A
Publication Date:
March 25, 2002
Filing Date:
December 22, 1993
Export Citation:
Assignee:
Daiichi Pharmaceutical Co., Ltd.
International Classes:
A61K31/47; A61K31/4709; A61K31/5383; A61P31/00; A61P31/04; C07D215/233; C07D401/04; C07D471/04; C07D487/04; C07D491/04; C07D495/04; C07D497/04; A61K31/435; C07D498/04; C07D513/04; C07D519/00; (IPC1-7): C07D471/04; A61K31/4709; A61K31/5383; A61P31/00; C07D487/04; C07D491/04; C07D495/04; C07D497/04; C07D498/04; C07D513/04; C07D519/00
Domestic Patent References:
| JP2289583A | ||||
| JP2231475A | ||||
| JP6212760A | ||||
| JP7188230A |
Other References:
【文献】国際公開92/21659(WO,A1)
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