Title:
BICYCLIC KETO ACID* AMINO ACID AND THEIR ESTERS* AMIDES AND SALTS
Document Type and Number:
Japanese Patent JPS5653674
Kind Code:
A
Abstract:
Compounds of the formula: …… wherein R is COCO2R<2>, CH(NH2)CO2R<2> or CH(NH2)CONHR<3>, the compounds in which R is CH(NH2)CO2R<2> or CH(NH2)CONHR<3> being present in the L or DL (racemic) form; R<1> is hydrogen, lower alkyl or phenyl; said phenyl being optionally substituted with one or more hydroxy, lower alkoxy or lower alkyl groups or halogen atoms; R<2> is hydrogen or lower alkyl; R<3> is hydrogen, lower alkyl, lower alkoxy-lower alkyl, or benzyl said benzyl group being optionally substituted in the phenyl ring with one or more hydroxy, lower alkoxy or lower alkyk groups or halogen atoms; X is oxygen or sulphur; n is 0 or 1; the dotted line represents an optional double bond; and pharmaceutically acceptable salts thereof are useful in treating diseases and medical conditions, which are characterised by reduced blood flow, reduced oxygen availability or reduced carbohydrate metabolism in the cardiovascular system of the subject, such as angina pectoris or cardiac failure, and in diabetes.
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Inventors:
AIAN TONPUSON BAANITSUSHIYU
PIITAA EDOWAADO KUROSU
PIITAA EDOWAADO KUROSU
Application Number:
JP12845680A
Publication Date:
May 13, 1981
Filing Date:
September 16, 1980
Export Citation:
Assignee:
PFIZER
International Classes:
A61K31/34; A61K31/343; A61K31/35; A61K31/352; A61K31/38; A61K31/381; A61K31/382; A61P9/00; A61P9/10; C07D307/79; C07D311/58; C07D333/54; C07D335/06; (IPC1-7): A61K31/34; A61K31/35; A61K31/38; C07D307/79; C07D311/04; C07D333/54; C07D335/06
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