Title:
BICYCLIC LACTAM, MANUFACTURE AND BLEND CONTAINING SAME
Document Type and Number:
Japanese Patent JPS6178767
Kind Code:
A
Abstract:
Bicyclic lactams of the general formula I (I) in which R1 and R2, which can be identical or different, denote a hydrogen atom or an alkyl group with 1 to 3 carbon atoms, R3 denotes an unsubstituted phenyl group or a phenyl group which is substituted by a halogen atom, one or two alkoxy groups, a methylenedioxo group or one or several hydroxyl groups, or denotes a pyridyl group, an indolyl group, a 1,2-benzisoxazolyl group which is optionally substituted by a halogen atom or the benzimidazol-2-one or 1,4-benzodioxane radical, R4 denotes a hydrogen atom or an alkyl group with 1 to 6 carbon atoms or a carbalkoxymethylen group, Z denotes a straight-chain, saturated or unsaturated alkylene group with 2 or 3 carbon atoms, which is optionally alkylated, X denotes an oxygen atom or a single bond and n denotes the number 1, 2 or 3, and their tautomeric forms and their salts and acid addition salts, block both the alpha and the beta receptors of the adrenergic system and are therefore suitable for the treatment of hypertension, circulatory disturbances, angina pectoris and coronary insufficiency.
Inventors:
COHNEN ERICH (DE)
JACOBITZ PETRA (DE)
JACOBITZ PETRA (DE)
Application Number:
JP20546485A
Publication Date:
April 22, 1986
Filing Date:
September 19, 1985
Export Citation:
Assignee:
BEIERSDORF AG (DE)
International Classes:
A61K31/47; A61K31/55; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P25/02; C07D215/22; C07D215/227; C07D223/16; C07D319/00; C07D401/12; C07D405/12; C07D413/12; (IPC1-7): A61K31/47; A61K31/55; C07D209/00; C07D213/00; C07D215/00; C07D215/22; C07D223/16; C07D235/00; C07D261/00; C07D319/00; C07D401/12; C07D405/12; C07D413/12
Attorney, Agent or Firm:
Heiyoshi Odashima