Title:
二環性含窒素縮合環化合物
Document Type and Number:
Japanese Patent JP4533583
Kind Code:
B2
Abstract:
The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R<1> denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R<2> denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R<3> denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR<4> (wherein R<4> denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR<4>.
Inventors:
Shigeki Hibi
Yoshinori Takahashi
Hoshino
Koichi Kikuchi
Takei Soejima
Tatsuya Yoshiuchi
Shin Kodama
Mutsuko Ono
Hisashi Shibata
Mitsuhiro Ino
Tetsuya Hirakawa
Yoshinori Takahashi
Hoshino
Koichi Kikuchi
Takei Soejima
Tatsuya Yoshiuchi
Shin Kodama
Mutsuko Ono
Hisashi Shibata
Mitsuhiro Ino
Tetsuya Hirakawa
Application Number:
JP2002563153A
Publication Date:
September 01, 2010
Filing Date:
February 08, 2002
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
A61K31/5025; C07D487/04; A61P1/00; A61P1/04; A61P1/14; A61P3/04; A61P3/10; A61P9/00; A61P9/02; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/00; A61P15/00; A61P15/08; A61P15/10; A61P15/12; A61P17/14; A61P19/10; A61P21/00; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P27/00; A61P27/06; A61P29/00; A61P31/18; A61P35/00; A61P37/04; A61P37/08; A61P43/00; C07D471/04
Domestic Patent References:
| JP3506033A | ||||
| JP2000502723A | ||||
| JP2004532792A | ||||
| JP10072449A | ||||
| JP2000109431A |
Foreign References:
| WO1999040090A1 | ||||
| US4596872 | ||||
| WO1998035967A1 |
Attorney, Agent or Firm:
Satoshi Furuya
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa