Title:
二環式オキソピリジン及びオキソピリミジン誘導体
Document Type and Number:
Japanese Patent JP2005505627
Kind Code:
A
Abstract:
Compounds of formulae (1a) and (1b) are described: in which the dashed line represents an optional bond; A is a -N- atom or a -N(Rb)-, -C(Rb)- or -C(Rb)(RC)- group; Ra, Rb and Rc is each independently a hydrogen atom or an optionally substituted C1-6alkyl group; X is an -O- or -S- atom or -NH- group or substituted N atom; each Y is independently a N atom or CH group or substituted C atom; n is zero or the integer 1; Alk1 is an optionally substituted aliphatic or heteroaliphatic chain L1 is a covalent bond or a linker atom or group; Cy1 is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof; The compounds are potent inhibitors of p38 kinase and are use in the prophylaxis or treatment of p38 kinase mediated diseases or disorders, such as rheumatoid arthritis
Inventors:
Davis Germy Martin
Brookings Daniel Christopher
Langham Barry John
Brookings Daniel Christopher
Langham Barry John
Application Number:
JP2003536241A
Publication Date:
February 24, 2005
Filing Date:
October 16, 2002
Export Citation:
Assignee:
Celtec R&D Limited
International Classes:
A61K31/4365; A61K31/437; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/02; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D471/04; C07D495/04; (IPC1-7): C07D471/04; A61K31/4365; A61K31/437; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/02; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D495/04
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama