Title:
ビシクロ[2.2.1]ヘプタ-7-イルアミン誘導体およびその使用
Document Type and Number:
Japanese Patent JP2009504624
Kind Code:
A
Abstract:
Compounds of formula (I) have muscarinic M3 receptor modulating activity;
wherein A is an oxygen atom or group -N(R 12 )-;
(i) R 1 is C 1 -C 6 -alkyl or a hydrogen atom; and R 2 is a hydrogen atom or a group -R 5 , -Z-Y-R 5 , -Z-NR 9 R 10 ; -Z-CO-NR 9 R 10 ; -Z-NR 9 -CO-R 5 ; or -Z-CO 2 H; and R 3 is a lone pair, or C 1 -C 6 -alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) R 1 and R 3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R 2 is a hydrogen atom; or a group -R 5 , -Z-Y-R 5 , -Z-NR 9 R 10 , -Z-CO-NR 9 R 10 , -Z-NR 9 -CO-R 5 , or-Z-CO 2 H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R 1 and R 2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group -Y-R 5 , -Z-Y-R 5 , -Z-NR 9 R 10 ; -Z-CO-NR 9 R 10 ; -Z-NR 9 -CO-R 5 ; or -Z-CO 2 H and R 3 is a lone pair, or C 1 -C 6 -alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; R 4 is a group of formula (a), (b), (c) or (d);
is an C 1 -C 6 -alkyl, aryl, aryl-fused-cycloalkyl, aryl-fused-heterocycloalkyl, heteroaryl, aryl(C 1 -C 8 -alkyl)-, heteroaryl(C 1 -C 8 -alkyl)-, cycloalkyl or heterocycloalkyl group, and the remaining variables are as defined in the specification.
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Inventors:
Harry finch
Nicholas Charles Ray
Richard James Bull
Monique Bodyle Fun Neil
Andrew Stephen Robert Jennings
Nicholas Charles Ray
Richard James Bull
Monique Bodyle Fun Neil
Andrew Stephen Robert Jennings
Application Number:
JP2008525627A
Publication Date:
February 05, 2009
Filing Date:
August 08, 2006
Export Citation:
Assignee:
Argenta Discovery Limited
International Classes:
C07C271/38; A61K31/381; A61K31/4704; A61P1/00; A61P1/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/00; A61P13/10; C07C217/14; C07C219/24; C07D333/24; C07D409/12
Domestic Patent References:
| JPH1171331A | 1999-03-16 | |||
| JP2003528076A | 2003-09-24 |
Foreign References:
| WO2003087094A2 | 2003-10-23 | |||
| WO2001042212A1 | 2001-06-14 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Samejima Mutsumi
Masahiro Nitta