BIFUNCTIONAL HISTONE DEACETYLASE INHIBITOR

Title:

BIFUNCTIONAL HISTONE DEACETYLASE INHIBITOR

Document Type and Number:

Japanese Patent JP2013018783

Kind Code:

A

Abstract:

To provide bifunctional histone deacetylase inhibitors.

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds.

Inventors:

BRADNER JAMES ELLIOT
MAZITSCHEK RALPH
TANG WEIPING
SCHREIBER STUART L

Application Number:

JP2012220357A

Publication Date:

January 31, 2013

Filing Date:

October 02, 2012

Export Citation:

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Assignee:

HARVARD COLLEGE
DANA FARBER CANCER INST INC

International Classes:

C07C251/86; A61K31/165; A61K31/167; A61K31/225; A61K31/23; A61K31/357; A61K31/4045; A61K31/422; A61K31/435; A61K45/00; A61P29/00; A61P35/00; A61P43/00; C07C249/16; C07C259/06; C07D209/14; C07D221/14; C07D319/06; C07D413/12; G01N33/15; G01N33/50; C07B61/00

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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