Title:
二官能性ヒストンデアセチラーゼインヒビター
Document Type and Number:
Japanese Patent JP5441416
Kind Code:
B2
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
Inventors:
Bradner, James Elliott
MAGIC CHECK, Ralph
Tan, weapin
Shriver, Stewart El.
MAGIC CHECK, Ralph
Tan, weapin
Shriver, Stewart El.
Application Number:
JP2008555470A
Publication Date:
March 12, 2014
Filing Date:
February 14, 2007
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C07C259/06; A61K31/16; A61K31/357; A61K31/4192; A61P17/00; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07D249/04; C07D319/06
Domestic Patent References:
| JP6001720A | ||||
| JP2004509105A | ||||
| JP2007518694A | ||||
| JP2002513419A | ||||
| JP2006519772A | ||||
| JP4022948A | ||||
| JP4217929A | ||||
| JP59139390A |
Foreign References:
| US20050014839 |
Other References:
Proceedings of the National Academy of Sciences,1991年,88,pp.5542-5546
Polyhedron,1999年,18,pp.2391-2398
International Journal for Parasitology,2000年,30,pp.761-768
Journal of Medicinal Chemistry,1970年,13(6),pp.1235-1237
Proceedings of the National Academy of Sciences of the United States of America,2004年,101(42),pp.15064-15069
MARMUSE,ORG. BIOMOL. CHEM,2005年 5月,V3,P2225-2227
Polyhedron,1999年,18,pp.2391-2398
International Journal for Parasitology,2000年,30,pp.761-768
Journal of Medicinal Chemistry,1970年,13(6),pp.1235-1237
Proceedings of the National Academy of Sciences of the United States of America,2004年,101(42),pp.15064-15069
MARMUSE,ORG. BIOMOL. CHEM,2005年 5月,V3,P2225-2227
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita