Title:
二官能性ポリアザ大環状キレート剤
Document Type and Number:
Japanese Patent JP2009529501
Kind Code:
A
Abstract:
A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
Inventors:
Kovacs, Zoltan
Keefer, Garry E
Ben Simone, Corrine
Shelley, A. Dean
Tyrusco, Jura
Keefer, Garry E
Ben Simone, Corrine
Shelley, A. Dean
Tyrusco, Jura
Application Number:
JP2008557566A
Publication Date:
August 20, 2009
Filing Date:
March 06, 2007
Export Citation:
Assignee:
MDS (Canada) Inc.
International Classes:
A61K31/395; C07D273/00; A61K33/06; A61K33/24; A61K33/26; A61K33/32; A61K33/34; A61K38/00; A61K39/395; A61K47/48; A61P35/00; C07D471/08
Domestic Patent References:
| JPH05112567A | 1993-05-07 | |||
| JP2004529763A | 2004-09-30 | |||
| JP2004532820A | 2004-10-28 |
Other References:
JPN6012049575; ＳＴＩＭＭＥＬ，Ｊ．Ｂ． ｅｔ ａｌ．: 'Ｙｔｔｒｉｕｍ-９０ Ｃｈｅｌａｔｉｏｎ Ｐｒｏｐｅｒｔｉｅｓ ｏｆ Ｔｅｔｒａａｚａｔｅｔｒａａｃｅｔｉｃ Ａｃｉｄ Ｍａｃｒｏｃｙｃｌｅｓ， Ｄｉｅｔｈｙｌｅｎｅｔｒｉａｍｉｎｅｐｅｎｔａａｃｅｔ' Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６， Ｎｏ．２, 1995, ｐ．２１９-２２５
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto
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