二官能性ポリアザ大環状キレート剤

Japanese Patent JP5503149

B2

A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.

WO/1999/032463	INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS
WO/1993/018042	DESOSAMINO DERIVATIVES OF MACROLIDES AS IMMUNOSUPPRESSANTS AND ANTIFUNGAL AGENTS
JP2001519420	INDUSTRIAL APPLICABILITY [Title of Invention] Adines containing 5,6-di-hydro- (1,4,2) dioxazine-3-yl group and their use as a bactericidal / fungicide.

Kovacs, Zoltan
Keefer, Garry E
Ben Simone, Corrine
Shelley, A. Dean
Tyrusco, Jura

JP2008557566A

May 28, 2014

March 06, 2007

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Nordion (Canada) Inc.

C07D273/00; A61K31/395; A61K33/06; A61K33/24; A61K33/26; A61K33/32; A61K33/34; A61K38/00; A61K39/395; A61K47/48; A61P35/00; C07D471/08

JP5112567A
JP2004529763A
JP2004532820A

STIMMEL,J.B. et al.,Yttrium-90 Chelation Properties of Tetraazatetraacetic Acid Macrocycles, Diethylenetriaminepentaacetic Acid Analogs, and a Novel Terpyridine Acyclic Chelator,Bioconjugate Chemistry,1995年,Vol.6, No.2,p.219-225

Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto

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