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Patent Searching and Data


Title:
BILE ACID DERIVATIVE, ITS PREPARATION AND ITS USE AS PHARMACEUTICAL
Document Type and Number:
Japanese Patent JP3403218
Kind Code:
B2
Abstract:

PURPOSE: To provide a new compound useful as an antiliphemic and for treating liver disorders with cholestasis with no side-effects, which has activity to decrease the cholesterol level in the serum and has high affinity for transport system of bile acid.
CONSTITUTION: This compound is a compound of the formula; Z(-X-GS)n [GS is a (modified) bile acid group in the form of free acid, ester, amide or salt or bile acid group derived on an alcohol group; X is a cross-linking group or covalent bond; Z is central cross-linking group; (n) is 3 or 4; but GS is linked through X]. For example, the compound is obtained by successively reacting tris(2-carboxyethyl)nitromethane with triethylamine and ethyl chloroformate in THF, then reacting the resulting compound with benzyl 3β-(2- aminoethoxy)-7α,12α-dihydroxycholanate, and hydrogenating the resulting compound.


Inventors:
Enhsen, Dr. Alfons
Glombik, Dr. Heiner
Kramer, Werner
Wess, Guenther
Application Number:
JP1993000140375
Publication Date:
May 06, 2003
Filing Date:
June 11, 1993
Export Citation:
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Assignee:
HOECHST AG
International Classes:
A61K31/575; A61P1/00; A61P3/00; A61P3/06; A61P7/00; C07H9/00; C07J9/00; C07J41/00; (IPC1-7): C07J41/00; A61K31/575; A61P3/06
Other References:
Bull.Chem.Soc.Jpn.,(1990),63(8),p.2323−7
Ukr,Khim.Zh.,(1970),36(2),p.196−8
Zh.Org.Khim.,(1967),3(9),p.1613−6
Zh.Org.Khim.,(1969),5(8),p.1479−82
Attorney, Agent or Firm:
高木 千嘉 (外2名)