Title:
BILE ACID DERIVATIVE, ITS PRODUCTION AND USE OF THE COMPOUND AS MEDICINE
Document Type and Number:
Japanese Patent JP3237882
Kind Code:
B2
Abstract:
PURPOSE: To prepare a bile acid derivative having high affinity for the specified bile acid transport system of the small intestine, inhibiting bile acid absorption in a concentration-dependent and competitive manner and effective for the treatment of all diseases for which the inhibition of gallic acid absorption in the small intestine is desirable.
CONSTITUTION: A bile acid derivative as the dimer of a compound of formula I (G1 and G2 are bile acid radicals or modified bile acid radicals in the form of free acids, esters or amides, salt forms and also forms derivatized on the alcohol groups; X is a bridge group or a covalent bond; G1 and G2 may optionally be bonded via X). The particularly preferable compd. is the one in which the bile acid radical G1 in the form derivatized on the alcohol group is bonded to X via a carbon atom C24, X is a bridge group, and the bile acid radical G2 in the form derivatized on the alcohol group is bonded to X via one of the C3-, C7- or C12-position such as a compd. of formula II.
Inventors:
Werner Kramer
Guilunter Vue
Ciute Juan Miulner
Horst neubauer
Guilunter Vue
Ciute Juan Miulner
Horst neubauer
Application Number:
JP34837791A
Publication Date:
December 10, 2001
Filing Date:
December 05, 1991
Export Citation:
Assignee:
HOECHST AKTIENGESELLSCHAFT
International Classes:
A61K31/58; A61P3/06; C07J9/00; C07J31/00; C07J41/00; C07J43/00; A61K31/575; (IPC1-7): C07J9/00; A61K31/575; A61K31/58; A61P3/06; C07J41/00; C07J43/00
Other References:
ＧＯＶＥＲＮＭＥＮＴ ＲＥＰＯＲＴＳ，Ａｎｎｏｕｎｃｅｍｅｎｔｓ ＆ Ｉｎｄｅｘ，１９９０−９−１，Ｖｏｌ．９０，Ｎｏ．１７，ＡＤ−Ａ２２０９５２，Ｔｅｃｈｎｉｃａｌ Ｒｅｐｏｒｔ Ｎｏ．３，
Attorney, Agent or Firm:
Chika Takagi (2 outside)