Title:
BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE
Document Type and Number:
Japanese Patent JP2019142892
Kind Code:
A
Abstract:
To provide therapeutic compositions and methods for treating or ameliorating hypercholemia and/or cholestatic liver disease.SOLUTION: A composition for use in treatment of hypercholemia comprises an apical sodium-dependent bile acid transporter inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof, where the treatment includes non-systemically administering to an individual in need thereof a therapeutically effective amount of the composition.SELECTED DRAWING: Figure 3
Inventors:
BRONISLAVA GEDULIN
MICHAEL GRAY
NIALL O'DONNELL
MICHAEL GRAY
NIALL O'DONNELL
Application Number:
JP2019070187A
Publication Date:
August 29, 2019
Filing Date:
April 01, 2019
Export Citation:
Assignee:
LUMENA PHARMACEUTICALS LLC
International Classes:
A61K45/00; A61K31/137; A61K31/155; A61K31/235; A61K31/38; A61K31/40; A61K31/4196; A61K31/4402; A61K31/4436; A61K31/452; A61K31/47; A61K31/4995; A61K31/505; A61K31/5377; A61K31/554; A61K31/575; A61K31/7042; A61K31/706; A61P1/16; C07D207/16; C07D213/38; C07D215/20; C07D239/60; C07D249/14; C07D281/10; C07D295/037; C07D295/13; C07D295/215; C07D337/08; C07D417/10; C07D487/08; C07H15/26; C07J9/00; C07J43/00
Domestic Patent References:
| JP2010509379A | 2010-03-25 | |||
| JP4497472B2 | 2010-07-07 | |||
| JP4711953B2 | 2011-06-29 | |||
| JP2002542208A | 2002-12-10 | |||
| JP6217939B2 | 2017-10-25 |
Foreign References:
| WO2010062861A2 | 2010-06-03 |
Other References:
田中直見ほか: "特集：黄疸を診る 非閉塞性黄疸の治療の進歩−肝内胆汁うっ滞", 消化器内視鏡, vol. 16, no. 1, JPN6021002555, 2004, pages 97 - 101, ISSN: 0004605489
JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 18, JPN6016025675, 2005, pages 5853 - 5868, ISSN: 0004433158
JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 18, JPN6016025675, 2005, pages 5853 - 5868, ISSN: 0004433158
Attorney, Agent or Firm:
Kazuhiro Kiyohara