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Title:
BINDER FOR COMPRESSION TABLET AND DIRECT COMPRESSION STARCH AS AN ENHANCER FOR VEHICLE IN THE CASE WHERE IT IS USED AS A DISINTEGRATOR
Document Type and Number:
Japanese Patent JP2001039894
Kind Code:
A
Abstract:

To obtain a composition that has markedly high hardness, manifests markedly swift disintegration rate and can form tablets or the like having good properties by using directly compressable starch flour.

This composition comprises (A) non-birefringent starch granules that are partially swollen and have a certain level of smoothness, (B) non- swollen and bire-fringent granules and (C) at least one of other excipients in which the ratios of the component B to the component A is 1/5-5/1. The ratio of the directly compressable starch to the excipient is preferably 1/10-10/1. In a preferred embodiment, this composition additionally 0.01-80 wt.% of active ingredients, for example, pharmacologically active substances, perfumes, sweeteners, detergents or the like. The starch to be used here has an average particle size of ≥50 μm and a moist content of 3-15%. This composition can be used for giving tablets and other unit drug forms of good qualities.


Inventors:
MICHAUD JACQUES LOIC MARIE
MEEUS LIESBETH MARIA FERNANDE
Application Number:
JP2000191122A
Publication Date:
February 13, 2001
Filing Date:
June 26, 2000
Export Citation:
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Assignee:
CERESTAR HOLDING BV
International Classes:
A61K47/36; A23L27/00; A61K9/20; A61K47/02; A61K47/10; A61K47/32; A61K47/38; B01J2/28; B01J2/30; C08B30/12; (IPC1-7): A61K47/36; A61K9/20; A61K47/02; A61K47/10; A61K47/32; A61K47/38; B01J2/28; B01J2/30
Domestic Patent References:
JPS55114300A1980-09-03
JPH04318001A1992-11-09
JPS4621471B1
JP4402758B22010-01-20
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)



 
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