BIOACTIVE COMPOSITION CONTAINING THIOCTIC ACID DERIVATIVE

Title:

BIOACTIVE COMPOSITION CONTAINING THIOCTIC ACID DERIVATIVE

Document Type and Number:

Japanese Patent JP2008050330

Kind Code:

A

Abstract:

To inexpensively provide a highly safe and bioactive thioctic acid derivative.

A method for inexpensively synthesizing the thioctic acid derivative in which an 8-22C hydrocarbon group which may have a branched bond or an unsaturated bond, an acyl group or a 9-100C polycyclic aromatic hydrocarbon is bonded to a thioctic acid derivative, and a bioactive composition containing the thioctic acid derivative are provided. The bioactive composition containing the thioctic acid derivative has safety and stability higher than those of conventional thioctic acid derivatives and is easily absorbed to cells and tissues. After the derivative is absorbed, thioctic acid concentration in the cells and the tissues can be enhanced, thioctic acid activity can be highly expressed in the cells and the tissues for a long period of time and biological effect wider than that of conventional derivatives can be expressed.

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Inventors:

ITO SHINOBU
NAKAMURA HIROYUKI

Application Number:

JP2006255033A

Publication Date:

March 06, 2008

Filing Date:

August 24, 2006

Export Citation:

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Assignee:

ITO KK
NAKAMURA HIROYUKI

International Classes:

A61K31/385; A23K1/16; A23L1/30; A23L33/12; A61K8/46; A61K8/49; A61K31/23; A61P3/04; A61P3/10; A61P9/10; A61P17/00; A61P17/02; A61P17/08; A61P17/10; A61P17/14; A61P17/16; A61P25/04; A61P25/20; A61P29/00; A61P31/00; A61P39/06; A61P43/00; A61Q5/00; A61Q19/00; C07D339/00; C12N1/00; C12N5/07; C12N5/09

Domestic Patent References:

JPH04331284A	1992-11-19
JPS62175415A	1987-08-01
JPS62175417A	1987-08-01
JPS56120611A	1981-09-22
JPS62275468A	1987-11-30
JP2006083147A	2006-03-30
JPH04331284A	1992-11-19
JPS62175415A	1987-08-01
JPS62175417A	1987-08-01
JPS56120611A	1981-09-22
JPS62275468A	1987-11-30
JP2006083147A	2006-03-30

Other References:

JPN6012012942; 辻智子: 'サプリメントと臨床検査-健康と食の安全性-１．alpha-リポ酸の生理作用' 臨床病理レビュー特集Ｎｏ．１３５, 200602, ｐ．８５-９１
JPN6012012943; ＢＩＥＷＥＮＧＡ，Ｇ．Ｐ．　ｅｔ　ａｌ: 'Ｔｈｅ　ｐｈａｒｍａｃｏｌｏｇｙ　ｏｆ　ｔｈｅ　ａｎｔｉｏｘｉｄａｎｔ　ｌｉｐｏｉｃ　ａｃｉｄ' Ｇｅｎ　ＰｈａｒｍａｃｏｌＶｏｌ．２９，　Ｎｏ．３, 1997, ｐ．３１５-３１
JPN6012012944; ＲＡＢＥＬＥＲ，Ｒ．: 'アリピュア（alpha-リポ酸）のキレ-ト化特性' Ｆｏｏｄ　Ｓｔｙｌｅ　２１Ｖｏｌ．１０，　Ｎｏ．９, 2006, ｐ．９８-１００
JPN6012012945; 杉下朋子　他: 'alpha-リポ酸のダイエットおよび美容機能' Ｎｅｗ　Ｆｏｏｄ　ＩｎｄＶｏｌ．４７，　Ｎｏ．４, 2005, ｐ．１６-２０
JPN6012012946; 重信隆史: '腱組織修復に関する実験的研究　血小板由来増殖因子（ＰＤＧＦ）の作用について' 広島大学医学雑誌Ｖｏｌ．４８，　Ｎｏ．１, 2000, ｐ．１-１６
JPN6012012947; ＧＯＮＺＡＬＥＺ-ＰＥＲＥＺ，Ｏ．　ｅｔ　ａｌ: 'ＴＨＥＲＡＰＥＵＴＩＣ　ＰＥＲＳＰＥＣＴＩＶＥＳ　ＯＮ　ＴＨＥ　ＣＯＭＢＩＮＡＴＩＯＮ　ＯＦ　ＡＬＰＨＡ-ＬＩＰＯＩＣ　ＡＣＩＤ　ＡＮＤ　ＶＩＴＡＭＩＮ　Ｅ' Ｎｕｔｒ　ＲｅｓＶｏｌ．２６，　Ｎｏ．１, 200601, ｐ．１-５
JPN6012012942; 辻智子: 'サプリメントと臨床検査-健康と食の安全性-１．alpha-リポ酸の生理作用' 臨床病理レビュー特集Ｎｏ．１３５, 200602, ｐ．８５-９１
JPN6012012943; ＢＩＥＷＥＮＧＡ，Ｇ．Ｐ．　ｅｔ　ａｌ: 'Ｔｈｅ　ｐｈａｒｍａｃｏｌｏｇｙ　ｏｆ　ｔｈｅ　ａｎｔｉｏｘｉｄａｎｔ　ｌｉｐｏｉｃ　ａｃｉｄ' Ｇｅｎ　ＰｈａｒｍａｃｏｌＶｏｌ．２９，　Ｎｏ．３, 1997, ｐ．３１５-３１
JPN6012012944; ＲＡＢＥＬＥＲ，Ｒ．: 'アリピュア（alpha-リポ酸）のキレ-ト化特性' Ｆｏｏｄ　Ｓｔｙｌｅ　２１Ｖｏｌ．１０，　Ｎｏ．９, 2006, ｐ．９８-１００
JPN6012012945; 杉下朋子　他: 'alpha-リポ酸のダイエットおよび美容機能' Ｎｅｗ　Ｆｏｏｄ　ＩｎｄＶｏｌ．４７，　Ｎｏ．４, 2005, ｐ．１６-２０
JPN6012012946; 重信隆史: '腱組織修復に関する実験的研究　血小板由来増殖因子（ＰＤＧＦ）の作用について' 広島大学医学雑誌Ｖｏｌ．４８，　Ｎｏ．１, 2000, ｐ．１-１６
JPN6012012947; ＧＯＮＺＡＬＥＺ-ＰＥＲＥＺ，Ｏ．　ｅｔ　ａｌ: 'ＴＨＥＲＡＰＥＵＴＩＣ　ＰＥＲＳＰＥＣＴＩＶＥＳ　ＯＮ　ＴＨＥ　ＣＯＭＢＩＮＡＴＩＯＮ　ＯＦ　ＡＬＰＨＡ-ＬＩＰＯＩＣ　ＡＣＩＤ　ＡＮＤ　ＶＩＴＡＭＩＮ　Ｅ' Ｎｕｔｒ　ＲｅｓＶｏｌ．２６，　Ｎｏ．１, 200601, ｐ．１-５

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