Title:
インシュリン類似体のためのバイオ分析方法
Document Type and Number:
Japanese Patent JP6893214
Kind Code:
B2
Abstract:
The present invention provides for a specific and sensitive bio-analytical method for detection of insulin or insulin analogues in plasma, serum or any other biological fluid, wherein the insulin or insulin analogues are labelled with a stable isotopic nitrogen for detection by the use of solid phase extraction and liquid chromatography with tandem mass spectrometric detection.
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Inventors:
Buddha, Madhavan
Patare, Mukesh, Bee.
Anedo, Kedkar
Tagore, Ranitene Dranato
McDonald's, Sebastian, Alastair
Patare, Mukesh, Bee.
Anedo, Kedkar
Tagore, Ranitene Dranato
McDonald's, Sebastian, Alastair
Application Number:
JP2018535323A
Publication Date:
June 23, 2021
Filing Date:
January 20, 2017
Export Citation:
Assignee:
Biocon Limited
International Classes:
G01N30/72; G01N27/62; G01N30/88; G01N33/58; G01N33/68
Domestic Patent References:
| JP2002332295A | ||||
| JP2014505869A | ||||
| JP2018511812A | ||||
| JP2009511039A | ||||
| JP2011510677A |
Foreign References:
| WO2004029254A1 | ||||
| US20100311176 | ||||
| US20030119109 |
Other References:
RODRIGUEZ-CABALEIRO, Diego et al.,Pilot Study for the Standardization of Insulin Immunoassays with Isotope Dilution-Liquid Chromatography/Tandem Mass Spectrometry,Clinical Chemistry,2007年,Vol.53, No.8,pp.1462-1469, [online], [令和2年8月27日検索], インターネット,URL,
KIPPEN, Alistair D. et al.,Development of an Isotope Dilution Assay for Precise Determination of Insulin, C-peptide, and Proinsulin Levels in Non-diabetic and Type II Diabetic Indivisuals with Comparison to Immunoassay,The Journal of Biological Chemistry,1997年,Vol.272, No.19,pp.12513-12522, [online], [令和2年8月27日検索], インターネット,URL,
KIPPEN, Alistair D. et al.,Development of an Isotope Dilution Assay for Precise Determination of Insulin, C-peptide, and Proinsulin Levels in Non-diabetic and Type II Diabetic Indivisuals with Comparison to Immunoassay,The Journal of Biological Chemistry,1997年,Vol.272, No.19,pp.12513-12522, [online], [令和2年8月27日検索], インターネット,URL,
Attorney, Agent or Firm:
Kiyoji Kuzuwa