Title:
ナノ粒子を水性媒質に分散させるための、イガイ類接着タンパク質模倣型ポリマーを用いた生体適合性分散安定化剤
Document Type and Number:
Japanese Patent JP5766808
Kind Code:
B2
Abstract:
Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
Inventors:
Haeyoung, Daegwan
Na, kun
Lynn, Daishung
Park, oolam
Na, kun
Lynn, Daishung
Park, oolam
Application Number:
JP2013527025A
Publication Date:
August 19, 2015
Filing Date:
December 28, 2011
Export Citation:
Assignee:
Hanwa Chemical Corporation
International Classes:
C08G81/00; A61K49/00; B82Y5/00; B82Y40/00; C08K3/00; C08L87/00; C09K23/16; C09K23/22; C09K23/42; C09K23/52
Domestic Patent References:
| JP2008069092A | ||||
| JP2010501027A | ||||
| JP2003528163A | ||||
| JP2010530013A |
Foreign References:
| WO2008143061A1 |
Attorney, Agent or Firm:
Koji Nagato