生分解性化合物、脂質粒子、脂質粒子を含むキット、脂質粒子を利用した活性剤送達方法、および細胞の作製方法

Title:

生分解性化合物、脂質粒子、脂質粒子を含むキット、脂質粒子を利用した活性剤送達方法、および細胞の作製方法

Document Type and Number:

Japanese Patent JP7431929

Kind Code:

B2

Abstract:

The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR₂ (1)whereinQ is represented by the following formula (1-Q): R^Q1₂N-(CR^Q2₂)_q1-NR^Q1-(CR^Q2₂)_q2-* (1-Q)whereineach R^Q1 is independently an alkyl,each R^Q2 is independently hydrogen or an alkyl,any two of R^Q1s and R^Q2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR₂; andeach R is independently an aliphatic group of C₁₂ to C_24;wherein said R is represented by the following formula (1-R): -L^R1-C(=O)-O-L^R2 (1-R)whereL^R1 is alkylene andL^R2 is represented by the following formula (1-R2): -CH₂-CH=CH-(CH₂)_r2-H (1-R2)where r2 is an integer of 1 to 10.

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Inventors:

Mitsuko Ishihara
Eiichi Akahoshi
Katsuyuki Naito
Emi Nozaki
Saeko Saruwatari

Application Number:

JP2022189553A

Publication Date:

February 15, 2024

Filing Date:

November 28, 2022

Export Citation:

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Assignee:

Toshiba Corporation

International Classes:

C07C229/24; A61K9/127; A61K31/7088; A61K31/7105; A61K31/711; A61K31/713; A61K47/18; A61K47/22; A61K47/28; A61K47/34; A61P43/00; C07D233/02; C07D243/08; C07D295/13; C07D295/15; C12N15/88

Domestic Patent References:

JP6997862B2
JP7209066B2
JP2015500835A
JP2017522376A

Foreign References:

WO2019176079A1
WO2017111172A1
WO2016210190A1
WO2017222016A1

Other References:

Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids,Journal of Controlled Release,2005年,Vol.107,pp.276-287

Attorney, Agent or Firm:

Manabu Miyajima
Takeshi Sekine
Jun Suzuki
Hideaki Maekawa

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