Title:
逆熱ゲル化特性を有する生分解性低分子量トリブロックポリエステルポリエチレングリコールコポリマー
Document Type and Number:
Japanese Patent JP4628545
Kind Code:
B2
Abstract:
A water soluble, biodegradable ABA- or BAB-type tri-block polymer is disclosed that is made up of a major amount of a hydrophobic A polymer block made of a biodegradable polyester and a minor amount of a hydrophilic polyethylene glycol(PEG) B polymer block, having an overall average molecular weight of between about 2000 and 4990, and that possesses reverse thermal gelation properties. Effective concentrations of the tri-block polymer and a drug may be uniformly contained in an aqueous phase to form a drug delivery composition. At temperatures below the gelation temperature of the tri-block polymer the composition is a liquid and at temperatures at or above the gelation temperature the composition is a gel or semi-solid. The composition may be administered to a warm-blooded animal as a liquid by parenteral, ocular, topical, inhalation, transdermal, vaginal, transurethral, rectal, nasal, oral, pulmonary or aural delivery means and is a gel at body temperature. The composition may also be administered as a gel. The drug is released at a controlled rate from the gel which biodegrades into non-toxic products. The release rate of the drug may be adjusted by changing various parameters such as hydrophobic/hydrophilic component content, polymer concentration, molecular weight and polydispersity of the tri-block polymer. Because the tri-block polymer is amphiphilic, it functions to increase the solubility and/or stability of drugs in the composition.
Inventors:
Rashi, Ramesh Shee
Gehent M. Zentner
Chong, Byong Moon
Gehent M. Zentner
Chong, Byong Moon
Application Number:
JP2000572276A
Publication Date:
February 09, 2011
Filing Date:
September 30, 1999
Export Citation:
Assignee:
Procerix Salt Lake City, Incorporated
International Classes:
C08G63/66; C08G81/00; A61K9/00; A61K9/10; A61K9/107; A61K31/17; A61K31/282; A61K31/337; A61K31/437; A61K31/519; A61K31/704; A61K31/7042; A61K38/00; A61K38/04; A61K38/095; A61K38/17; A61K38/21; A61K38/22; A61K38/24; A61K38/26; A61K38/27; A61K38/28; A61K38/43; A61K39/00; A61K39/395; A61K45/00; A61K47/30; A61K47/32; A61K47/34; A61P35/00; C08G63/08; C08G63/664; C08G63/91; C08G65/329; C08L67/00; C08L67/04; C08L71/02; C08L101/16
Domestic Patent References:
| JP9100343A |
Foreign References:
| WO1997015287A1 | ||||
| WO1997019973A1 | ||||
| WO1997015389A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takako Koiso
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takako Koiso