Title:
生分解性水溶性ポリマー
Document Type and Number:
Japanese Patent JP5196498
Kind Code:
B2
Abstract:
The invention provides biodegradable, water soluble PEA, PEUR and PEU carrier polymers, which can be used to conjugate, and thereby stabilize and/or solubilize, bioactive agents via polar uncharged or charged groups and activated ester or amino groups contained in the building blocks that make up the backbone of the polymer. The bioactive agents are released at a controlled rate determined by biodegradation of the polymers. The highly versatile Active Polycondensation (APC) method, which is mainly carried out in solution at mild temperatures, readily allows synthesis of such polymers. The invention water soluble polymers can also be used as water solubilizing tethers to attach drugs, and biologics to the surface of such carrier constructs as liposomes, particles and micelles.
Inventors:
Rubber Rush Billy The Zade.
Turnel William Dee.
Basilev Basil Pea.
Chow Dali Naido Surinibasa
Turnel William Dee.
Basilev Basil Pea.
Chow Dali Naido Surinibasa
Application Number:
JP2009509850A
Publication Date:
May 15, 2013
Filing Date:
May 09, 2007
Export Citation:
Assignee:
Medibus LLC
International Classes:
C08G69/44; A61K9/127; A61K47/48; A61P43/00; C08L77/12
Domestic Patent References:
| JP2003519650A | ||||
| JP8027269A | ||||
| JP2004507600A | ||||
| JP2008542393A | ||||
| JP2008530206A |
Foreign References:
| WO2005097186A1 | ||||
| WO2005118681A1 |
Attorney, Agent or Firm:
Ikeda adult
Masakazu Noda
Yoshinori Shimizu
Kazuhiro Yamaguchi
Masakazu Noda
Yoshinori Shimizu
Kazuhiro Yamaguchi