BIOINFORMATICS METHOD FOR IDENTIFYING SURFACE-IMMOBILIZED PROTEIN ORIGINATED FROM GRAM POSITIVE BACTERIUM, AND PROTEIN OBTAINED THEREBY

Title:

BIOINFORMATICS METHOD FOR IDENTIFYING SURFACE-IMMOBILIZED PROTEIN ORIGINATED FROM GRAM POSITIVE BACTERIUM, AND PROTEIN OBTAINED THEREBY

Document Type and Number:

Japanese Patent JP2010142230

Kind Code:

A

Abstract:

To provide a bioinformatics method for identifying and isolating proteins having MSCRAMM(R) like character, originated from Gram positive bacteria, e.g. bacteria belonging to the genus Enterococcus, Staphylococcus, Streptococcus and Bacillus, and also capable of being utilized for the prevention and treatment of infectious diseases caused by the Gram positive bacteria.

This method for identifying MSCRAMM(R) proteins having a putative LPXTG cell wall-sorting signal on C-terminal region and having the proteins and the LPXTG-anchored cell wall proteins and other proteins having structural similarities from an amino acid sequence information is provided. The antibodies useful for the diagnosis, prevention and treatment of the infectious diseases caused by the Gram positive bacteria are produced by using the identified and isolated MSCRAMM(R) proteins and their immunogenic regions.

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Inventors:

HOOK MAGNUS
XU YI
SILLANPAA JOUKO V
STHANAM NARAYANA
PONNURAJ KARTHE
PATTI JOSEPH M
HUTCHINS JEFF T
HALL ANDREA
BOWDEN G MARIA

Application Number:

JP2009286834A

Publication Date:

July 01, 2010

Filing Date:

December 17, 2009

Export Citation:

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Assignee:

TEXAS A & M UNIV SYS
INHIBITEX INC
UAB RESEARCH FOUNDATION

International Classes:

C12N15/09; G01N33/53; A61K9/12; A61K35/16; A61K39/00; A61K39/02; A61K39/085; A61K39/09; A61K39/395; A61P31/04; C07K14/195; C07K14/315; C07K16/12; C07K16/28; C12P21/08; G01N33/543; G01N33/569; G01N33/68; G16B15/20; G16B30/00; A61K38/00

Domestic Patent References:

JP2000060553A	2000-02-29
JP2003515148A	2003-04-22
JP2002529046A	2002-09-03
JP2002516571A	2002-06-04

Foreign References:

WO2000068242A1	2000-11-16
WO1998050554A2	1998-11-12
US20020120116A1	2002-08-29
WO2001083691A2	2001-11-08

Other References:

JPN6009029915; ＤＥＩＶＡＮＡＹＡＧＡＭ，　Ｃ．Ｃ．　ｅｔ　ａｌ．: '"Ｎｏｖｅｌ　ｆｏｌｄ　ａｎｄ　ａｓｓｅｍｂｌｙ　ｏｆ　ｔｈｅ　ｒｅｐｅｔｉｔｉｖｅ　Ｂ　ｒｅｇｉｏｎ　ｏｆ　ｔｈｅ　Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ　ａｕｒｅｕｓ　ｃｏｌｌａｇｅｎ-ｂｉｎｄｉｎｇ　ｓｕ' ＳＴＲＵＣＴＵＲＥＶｏｌ．８，　Ｎｏ．１, 20000115, Ｐ．６７-７８

Attorney, Agent or Firm:

Takao Hamano
Teruichi Hirai

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