Title:
BIOMARKERS FOR PREDICTING ANTI-TNF RESPONSIVENESS OR NON-RESPONSIVENESS
Document Type and Number:
Japanese Patent JP2014033676
Kind Code:
A
Abstract:
To provide a method of predicting the response of a subject to a therapy comprising an anti-TNF agent.
The method comprises: providing a biological sample obtained from a subject that has an immune disorder; and measuring the expression level of one or more genes in the biological sample, where the one or more genes comprise at least one gene selected from the group consisting of ANKIB1, ARF1, ARF5, BRWD2, CALM2, CLTB, COL4A3BP, C9orf80, EGLN2, HDAC5, LGALS9, MYLIP, PCBP2, PGK1, RBBP4, RER1, RPA3, SERF2, SLC25A39, SRGAP2, TUG1, YIPF6, ZNF294, ZFP36L1, ANKRD12, CAMK2G-, CASP5, CXorf52, DNAH1, EEA1, FAM44A, FOXJ3, HDAC4, MNT, MXRA7, PTCH1, SEL1L, and SFRS2.
Inventors:
CARULLI JOHN P
GREGERSEN PETER K
BATLIWALLA FRANAK
BIENKOWSKA JADWIGA
LIU CHUNYU
GREGERSEN PETER K
BATLIWALLA FRANAK
BIENKOWSKA JADWIGA
LIU CHUNYU
Application Number:
JP2013226708A
Publication Date:
February 24, 2014
Filing Date:
October 31, 2013
Export Citation:
Assignee:
BIOGEN IDEC INC
THE FEINSTEIN INST MEDICAL RES
THE FEINSTEIN INST MEDICAL RES
International Classes:
C12N15/09; A61K31/7088; A61K45/00; A61K48/00; A61P1/04; A61P19/02; A61P29/00; A61P37/00; C12M1/00; C12M1/34; C12Q1/68; G01N33/53; G01N37/00
Foreign References:
| WO2007038501A2 | 2007-04-05 |
Other References:
JPN6015002354; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓ．， ２００５， ３３（３）， ｅ３１
Attorney, Agent or Firm:
Takeshi Oshio