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Title:
BIPHENYL DERIVATIVE, PRODUCTION THEREOF AND SYNTHETIC INTERMEDIATE THEREFOR
Document Type and Number:
Japanese Patent JPH02235884
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I {ring A represents sulfur- containing or oxygen-containing heteromonocyclic group optionally oxygen- containing heteromonocyclic group optionally having substituent group; ring B represents formula II or III [R4 represents (substituted) lower alkyl]; R1 to R3 represent H, halogen, lower alkoxy, etc.; Y represents methylene or carbonyl}.

EXAMPLE: 2-Formyl-4-oxo-γ-5-hydroxymethyl-t-7-(3,4-dimethoxyphen-yl)-4,5,6,7-te- trahydrobenzo[b]furan-c-6-carboxylic lactone.

USE: A therapeutic and prophylactic agent for liver disorder.

PREPARATION: A tetrahydrobiphenyl compound (salt) expressed by formula IV is treated with a fluorine ion donor and a salt thereof, as desired, is formed to afford the compound expressed by formula I wherein the ring B represents a group expressed by formula II.


Inventors:
IWASAKI TAMEO
SUGIURA MASAKI
MATSUOKA YUZO
MATSUMOTO MAMORU
KITAMURA KAZUYUKI
Application Number:
JP1989000057349
Publication Date:
September 18, 1990
Filing Date:
March 09, 1989
Export Citation:
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Assignee:
TANABE SEIYAKU CO
International Classes:
C07D333/54; A61K31/34; A61K31/365; A61K31/38; A61K31/381; A61P1/16; C07D307/79; C07D307/83; C07D333/64; C07D407/04; C07D409/04; C07D493/04; C07D495/04; (IPC1-7): A61K31/365; A61K31/38; C07D307/79; C07D333/54; C07D493/04; C07D495/04