Title:
代謝調節型グルタミン酸受容体-5のモジュレーターとしてのビピリジルアミン類およびエーテル類
Document Type and Number:
Japanese Patent JP2007504229
Kind Code:
A
Abstract:
The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.
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Inventors:
Kamenetka, Theodore M
Vernier, Jiyan-Mitzier
Bonneuf, Celine
Gobetsk, Stephen Pee
Hatsuchinson, Jiyoung H
Vernier, Jiyan-Mitzier
Bonneuf, Celine
Gobetsk, Stephen Pee
Hatsuchinson, Jiyoung H
Application Number:
JP2006525369A
Publication Date:
March 01, 2007
Filing Date:
August 27, 2004
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D213/69; A61K31/44; A61K31/444; A61K31/455; A61K31/4709; A61K31/4725; A61K31/497; A61K31/501; A61K31/506; A61K31/555; A61P1/14; A61P3/04; A61P25/00; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P39/00; A61P43/00; C07D213/74; C07D213/79; C07D213/84; C07D213/85; C07D401/10; C07D401/12; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D491/04; C07D491/048; C07F7/22
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura