Title:
BIS-AMINOMETHYL-ANTHRAQUINONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS57118540
Kind Code:
A
Abstract:
Bis-aminomethyl-anthraquinone derivs. of formula (I) and their salts with acids are new. R1 and R2 are each H or 1-4C alkyl, or R1 and R2 together form a 4-6C alkylene residue so that N(R1)(R2) is a 5- to 7-membered heterocyclic ring which may contain N, O or S as a further heteroatom and which may be substd. by 1-4C alkyl; and R3 is H or OH). The new cpds. can be used for combatting protozoal diseases, in humans and animals, e.g. amoebiasis due to Entamoeba histolytica. In addn., the cpds. have a direct or (due to interferon-induction) indirect activity against influenza and encephalomyocarditis viruses. On account of their interferon-inducing activity, the cpds. can be used against virus and cancer diseases. In addition, the new cpds. (esp. those in which R3 is OH) are effective against trichomoniasis.
More Like This:
Inventors:
EAHARUTO BUINKERUMAN
BUORUFUGANGU RAETERU
HAINRITSUHI RORII
BUORUFUGANGU RAETERU
HAINRITSUHI RORII
Application Number:
JP18557481A
Publication Date:
July 23, 1982
Filing Date:
November 20, 1981
Export Citation:
Assignee:
HOECHST AG
International Classes:
C07D295/10; A61K31/135; A61K31/165; A61K31/40; A61K31/445; A61K31/4468; A61K31/495; A61K31/535; A61K31/5375; A61K31/55; A61P31/12; A61P33/02; A61P35/00; C07C46/00; C07C50/24; C07C50/34; C07C225/34; C07D207/06; C07D207/08; C07D211/14; C07D211/26; C07D211/58; C07D243/08; C07D265/30; C07D295/116; (IPC1-7): A61K31/165; A61K31/40; A61K31/445; A61K31/495; A61K31/535; A61K31/55; C07C97/24; C07D207/08; C07D211/14; C07D211/58; C07D243/08; C07D265/30; C07D295/10