Title:
ビス−オクタヒドロフェナントレンカルボキサミド及びそのタンパク質コンジュゲート
Document Type and Number:
Japanese Patent JP2020520926
Kind Code:
A
Abstract:
本明細書に提供されるのは、ビス-オクタヒドロフェナントレンカルボキサミド及びそのタンパク質(例えば、抗体)薬物コンジュゲートを含む、肝臓X受容体と関連する疾患及び障害の治療のための化合物、組成物、及び方法である。【選択図】図１１
Inventors:
Amy Han
Andrew Jay Murphy
William Olson
Andrew Jay Murphy
William Olson
Application Number:
JP2019563612A
Publication Date:
July 16, 2020
Filing Date:
May 09, 2018
Export Citation:
Assignee:
Regeneron Pharmaceuticals, Inc.
International Classes:
C07C233/90; A61K39/395; A61K47/68; A61P3/00; A61P3/06; A61P9/10; A61P25/00; A61P29/00; C07D225/08; C07D233/64; C07D249/16; C07F9/09; C07H15/24; C07K5/02; C07K7/02; C07K16/28; C08B37/16
Domestic Patent References:
| JP2008503547A | 2008-02-07 | |||
| JP2003516327A | 2003-05-13 | |||
| JP2016534995A | 2016-11-10 | |||
| JP2007161712A | 2007-06-28 |
Foreign References:
| US20030125357A1 | 2003-07-03 | |||
| WO2015200078A1 | 2015-12-30 | |||
| US20160324981A1 | 2016-11-10 |
Other References:
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BARDYSHEV, I. I.: "Diterpenoid carboxylic acid anhydrides of the abietane, pimarane, and isopimarane series", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (TRANSLATION OF ZHURNAL ORGANICHESKOI KHIMII), vol. 35(1),, JPN6022011198, 1999, pages 41 - 55, ISSN: 0004958973
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE, US; RETRIEVED FROM STN, JPN7022001256, 16 November 1984 (1984-11-16), ISSN: 0004958974
SINGH S B: "DISCOVERY AND DEVELOPMENT OF DIMERIC PODOCARPIC ACID LEADS AS POTENT AGONISTS 以下備考", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. VOL:15, NR:11,, JPN5020007011, 2 June 2005 (2005-06-02), NL, pages 2824 - 2828, ISSN: 0004958975
COLIN M TICE: "THE MEDICINAL CHEMISTRY OF LIVER X RECEPTOR (LXR) MODULATORS", JOURNAL OF MEDICINAL CHEMISTRY, vol. VOL:57, NR:17,, JPN5020007010, 11 September 2014 (2014-09-11), pages 7182 - 7205, ISSN: 0004958976
ZHOU, TAO-TAO; HE, LING; YAN, MING; ZHANG, LU-YONG; HE, JIAN-GUO; RAO, XIAO-PING: "Tyrosine kinase inhibitory activity of dehydroabietylamine derivatives tested by homogeneous time-re", ZHONGGUO TIANRAN YAOWU, vol. 11(5),, JPN6022011195, 2013, pages 506 - 513, XP055220335, ISSN: 0004737343
ZEISS, HAROLD H.; MARTIN, WM. B., JR.: "Synthesis and stereochemistry of the 3-keto-Δ4-steroidal system from diterpenic acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 75, JPN6022011194, 1953, pages 5935 - 40, XP055494838, ISSN: 0004737344, DOI: 10.1021/ja01119a045
BIBLE R H: "THE CONVERSION OF PODOCARPIC ACID TO NIMBIOL", TETRAHEDRON, vol. VOL:11, NR:1-2,, JPN5020007012, 1960, pages 22 - 29, ISSN: 0004737345
BARDYSHEV, I. I.: "Diterpenoid carboxylic acid anhydrides of the abietane, pimarane, and isopimarane series", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (TRANSLATION OF ZHURNAL ORGANICHESKOI KHIMII), vol. 35(1),, JPN6022011198, 1999, pages 41 - 55, ISSN: 0004958973
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE, US; RETRIEVED FROM STN, JPN7022001256, 16 November 1984 (1984-11-16), ISSN: 0004958974
SINGH S B: "DISCOVERY AND DEVELOPMENT OF DIMERIC PODOCARPIC ACID LEADS AS POTENT AGONISTS 以下備考", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. VOL:15, NR:11,, JPN5020007011, 2 June 2005 (2005-06-02), NL, pages 2824 - 2828, ISSN: 0004958975
COLIN M TICE: "THE MEDICINAL CHEMISTRY OF LIVER X RECEPTOR (LXR) MODULATORS", JOURNAL OF MEDICINAL CHEMISTRY, vol. VOL:57, NR:17,, JPN5020007010, 11 September 2014 (2014-09-11), pages 7182 - 7205, ISSN: 0004958976
ZHOU, TAO-TAO; HE, LING; YAN, MING; ZHANG, LU-YONG; HE, JIAN-GUO; RAO, XIAO-PING: "Tyrosine kinase inhibitory activity of dehydroabietylamine derivatives tested by homogeneous time-re", ZHONGGUO TIANRAN YAOWU, vol. 11(5),, JPN6022011195, 2013, pages 506 - 513, XP055220335, ISSN: 0004737343
ZEISS, HAROLD H.; MARTIN, WM. B., JR.: "Synthesis and stereochemistry of the 3-keto-Δ4-steroidal system from diterpenic acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 75, JPN6022011194, 1953, pages 5935 - 40, XP055494838, ISSN: 0004737344, DOI: 10.1021/ja01119a045
BIBLE R H: "THE CONVERSION OF PODOCARPIC ACID TO NIMBIOL", TETRAHEDRON, vol. VOL:11, NR:1-2,, JPN5020007012, 1960, pages 22 - 29, ISSN: 0004737345
Attorney, Agent or Firm:
Toru Ishikawa