BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF

Title:

BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF

Document Type and Number:

Japanese Patent JP2023113639

Kind Code:

A

Abstract:

To provide novel bis-octahydrophenanthrene carboxamides effective for treating diseases and disorders associated with the liver X receptor by forming protein (e.g., antibody) drug conjugates.SOLUTION: The invention provides a compound of Formula I or a pharmaceutically acceptable salt, solvate or stereoisomeric form thereof. (In the formula, Q1 and Q2 are each CH2, C(O), or the like; W is CH2, N(H), or the like; R1 and R2 are each H, OH, or the like; R7 is halogen, C1-6 alkyl, or the like; and n is an integer from 0 to 3.)SELECTED DRAWING: Figure 11

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WO/2020/106780	BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS
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Inventors:

AMY HAN
KEBBEDE ANTENEH
WILLIAM OLSON

Application Number:

JP2023077334A

Publication Date:

August 16, 2023

Filing Date:

May 09, 2023

Export Citation:

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Assignee:

REGENERON PHARMA

International Classes:

C07C233/90; A61K39/395; A61K47/68; A61P3/00; A61P3/06; A61P9/10; A61P25/00; A61P29/00; C07C237/04; C07C271/30; C07D225/08; C07D233/64; C07D249/16; C07F9/12; C07H15/24; C08B37/16

Attorney, Agent or Firm:

Toru Ishikawa

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