Title:
二重特異性抗体並びにその製造方法及び使用方法
Document Type and Number:
Japanese Patent JP7418326
Kind Code:
B2
Abstract:
The disclosure provides bispecific antibodies having the binding specificity to at least two of human CTLA4, PD-1 or PD-L1. In one embodiment, the bispecific antibody comprises IgG domains having heavy chains and light chains, and two scFv components being connected to either C-terminal of the heavy chains or N-terminal of the light chains, wherein the IgG domains have the binding specificity to a first antigen, wherein the scFv components have the binding specificity to a second antigen, and wherein the first antigen and the second antigen are different and are independently selected from a-CTLA4, α-PD-1, and α-PD-L1.
Inventors:
two, i
Buykova, Katrina
brady, bill
Renshaw, Blair
Shea, Don
Gao, Zelen
Kovacevich, Bryan
Fallen, Jonathan Kaye.
Tan, Phil
Buykova, Katrina
brady, bill
Renshaw, Blair
Shea, Don
Gao, Zelen
Kovacevich, Bryan
Fallen, Jonathan Kaye.
Tan, Phil
Application Number:
JP2020524012A
Publication Date:
January 19, 2024
Filing Date:
November 01, 2018
Export Citation:
Assignee:
SYSTIMMUNE, INC.
International Classes:
C12N15/62; A61K39/395; A61P35/00; C07K16/28; C07K16/30; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63; C12P21/08
Domestic Patent References:
| JP2014523401A | ||||
| JP2008537941A | ||||
| JP2005528925A |
Foreign References:
| WO2014209804A1 | ||||
| WO2016061142A1 | ||||
| US20170073418 | ||||
| CN104974253A | ||||
| CN104987421A | ||||
| WO2017106061A1 |
Attorney, Agent or Firm:
SK Patent Attorney Corporation
Akihiko Okuno
Hiroyuki Ito
Akihiko Okuno
Hiroyuki Ito