二重特異性抗体ＣＡＲ細胞免疫療法

Title:

二重特異性抗体ＣＡＲ細胞免疫療法

Document Type and Number:

Japanese Patent JP7202689

Kind Code:

B2

Abstract:

Described herein are single vectors that, when expressed in cytolytic immune cells, results in both the expression of (1) a CAR targeting tumor-associated antigens and (2) secretion of a bispecific antibody that on one end recognizes NKG2D expressed on both innate and antigen specific cytolytic immune cells and on the other end targets tumor associated antigens. Unexpectedly, these modifications to the T cells result in enhanced survival and proliferation in vivo. Thus, therapeutic and diagnostic uses are disclosed.

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Inventors:

Yu, Zhenhua
Karijuri, Michael

Application Number:

JP2020547390A

Publication Date:

January 12, 2023

Filing Date:

March 15, 2019

Export Citation:

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Assignee:

CytoImmune Therapeutics, Inc.

International Classes:

C12N15/63; A61K35/12; A61K35/15; A61K35/17; A61K39/395; A61K45/00; A61K48/00; A61P35/00; A61P37/04; A61P43/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/62; C12N15/861; C12N15/864; C12N15/867

Domestic Patent References:

JP2017527271A
JP2015524255A

Foreign References:

WO2016134371A2
WO2017079705A1

Attorney, Agent or Firm:

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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