To provide a bispecific antibody which substitutes for functional protein, more particularly, a bispecific antibody which substitutes for a ligand function to a heteroreceptor, a bispecific antibody which substitutes for a function of a cofactor which reinforces enzyme reaction and a medicinal composition containing the antibody as an active ingredient.
The bispecific antibody substitutes for the ligand function to an I-type interferon receptor composed of two kind of molecules of AR1 chain and AR2 chain. In addition, the bispecific antibody substitutes for the function of a blood coagulation factor VIII/an activated blood coagulation factor VIII which reinforces the enzyme reaction by combining with both of a blood coagulation factor IX/an activated blood coagulation factor IX and a blood coagulation factor X.
KOJIMA TETSUO
MIYAZAKI TARO
SOEDA TETSUHIRO
SENOO CHIAKI
NATORI OSAMU
KASUYA KEIKO
ISHII SHINYA
| JP2003055398A | 2003-02-26 | |||
| JP2003509049A | 2003-03-11 |
| WO2003035835A2 | 2003-05-01 |
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Koichi Niimi