Title:
ブロック・コポリマおよびその形成方法、ならびに、それから形成されるミセル粒子
Document Type and Number:
Japanese Patent JP7141786
Kind Code:
B2
Abstract:
The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.
Inventors:
Hedrick, James
Body, Dylan
Woz Techchi, Rudy
Park, natalie
Febre, Mareba
Garcia, Janet
Yang, Yi, Yang
Chin, Willie
Leon, Eunice
Body, Dylan
Woz Techchi, Rudy
Park, natalie
Febre, Mareba
Garcia, Janet
Yang, Yi, Yang
Chin, Willie
Leon, Eunice
Application Number:
JP2020550934A
Publication Date:
September 26, 2022
Filing Date:
November 30, 2018
Export Citation:
Assignee:
INTERNATIONAL BUSINESS MACHINES CORPORATION
International Classes:
C08G64/18; A61K9/10; A61K31/704; A61K45/00; A61K47/34; A61P35/00; C08G64/42
Domestic Patent References:
| JP2013522178A | ||||
| JP2017002280A |
Other References:
J. Yue et al.,Transferrin-Conjugated Micelles: Enhanced Accumulation andAntitumor Effect for Transferrin-Receptor-Overexpressing Cancer Models,Mol. Pharmaceutics,2012年05月22日,9,1919-1931,10.1021/mp300213g
J. Yue et al.,Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction,Macromolecules,2010年11月15日,43,9645-9654,10.1021/ma101960d
J. Yue et al.,Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction,Macromolecules,2010年11月15日,43,9645-9654,10.1021/ma101960d
Attorney, Agent or Firm:
Tadashi Taneichi
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