Title:
ウーロン茶又は紅茶から抽出された血糖値上昇抑制剤及びミトコンドリア膜電位上昇剤
Document Type and Number:
Japanese Patent JP5439644
Kind Code:
B2
Abstract:
[Problem] To provide a new pharmacological action for high-molecular-weight polyphenols [Solution] To provide high-molecular-weight polyphenols extracted from fermented tea (e.g. oolong tea or black tea), which are high-molecular-weight polyphenols with a number average molecular weight ranging from 9,000 to 18,000, and containing in their partial structures a procyanidin structure of polymerized catechins and/or their gallates, and a structure of linkage between the B-rings of catechins and/or their gallates. These high-molecular-weight polyphenols have the functions of mitochondrial activation, suppression of increase in blood glucose, and suppression of weight gain. Therefore, they can be used as drugs for the treatment of mitochondrial disease, and also as drugs for the prevention and treatment of diabetes. They may also be added to health foods and beverages. The selected drawing shows changes in blood glucose level when the said high-molecular-weight polyphenols are given daily to diabetes model mice in specified doses.
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Inventors:
Numata Osamu
Takashi Fujiwara
Kazuaki Hosoda
Tetsuo Ozawa
Takashi Fujiwara
Kazuaki Hosoda
Tetsuo Ozawa
Application Number:
JP2006542450A
Publication Date:
March 12, 2014
Filing Date:
November 04, 2005
Export Citation:
Assignee:
University of Tsukuba
International Classes:
A61K36/18; A61K31/765; A61K36/00; A61P3/10; A23F3/16; A23L1/30; A23L2/52; A61P25/00; A61P25/08; A61P43/00
Other References:
JPN6012006457; Ｊ． Ａｇｒｉｃ． Ｆｏｏｄ Ｃｈｅｍ． Ｖｏｌ．５０, 2002, ｐｐ．７１８２-７１８６
JPN6012006458; Ｚｏｏｌ． Ｓｃｉ． Ｖｏｌ．１８ Ｎｏ．Ｓｕｐｐｌ．, 2001, ｐ．３３
JPN6012006459; Ｚｏｏｌ． Ｓｃｉ． Ｖｏｌ．２０ Ｎｏ．１２, 2003, ｐ．１５４７
JPN6012006462; 日本栄養・食糧学会総会講演要旨集 Ｖｏｌ．５５ｔｈ, 2001, ｐ．１８２
JPN6012006460; 肥満研究 Ｖｏｌ．１０ Ｎｏ．Ｓｕｐｐｌ．, 200409, ｐ．１３３
JPN6012059239; 肥満研究 Ｖｏｌ．１０ Ｎｏ．Ｓｕｐｐｌ．, 200409, ｐ．１８２ 左欄
JPN6012059241; 肥満研究 Ｖｏｌ．１０ Ｎｏ．Ｓｕｐｐｌ．, 200409, ｐ．１８２ 右欄
JPN6012059243; Ｂｉｏｓｃｉ． Ｂｉｏｔｅｃｈ． Ｂｉｏｃｈｅｍ． Ｖｏｌ．６０ Ｎｏ．１２, 1996, ｐｐ．２０２３-２０２７
JPN6012001696; 日本臨床生理学会雑誌 Ｖｏｌ．３０ 臨時増刊号, 200010, ｐ．６１
JPN6012001699; 糖尿病 Ｖｏｌ．４２ Ｎｏ．２, 1999, ｐｐ．１２７-１３０
JPN6012059245; Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ ＡＮ ２００５：２０８５９６
JPN6012059247; Ｊ． Ｐｈａｒｍ． Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．４７, 1995, ｐｐ．１３８-１４２
JPN6012059249; Ｂｉｏｃｈｅｍ． Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．６１, 2001, ｐｐ．１５５-１６４
JPN6012006458; Ｚｏｏｌ． Ｓｃｉ． Ｖｏｌ．１８ Ｎｏ．Ｓｕｐｐｌ．, 2001, ｐ．３３
JPN6012006459; Ｚｏｏｌ． Ｓｃｉ． Ｖｏｌ．２０ Ｎｏ．１２, 2003, ｐ．１５４７
JPN6012006462; 日本栄養・食糧学会総会講演要旨集 Ｖｏｌ．５５ｔｈ, 2001, ｐ．１８２
JPN6012006460; 肥満研究 Ｖｏｌ．１０ Ｎｏ．Ｓｕｐｐｌ．, 200409, ｐ．１３３
JPN6012059239; 肥満研究 Ｖｏｌ．１０ Ｎｏ．Ｓｕｐｐｌ．, 200409, ｐ．１８２ 左欄
JPN6012059241; 肥満研究 Ｖｏｌ．１０ Ｎｏ．Ｓｕｐｐｌ．, 200409, ｐ．１８２ 右欄
JPN6012059243; Ｂｉｏｓｃｉ． Ｂｉｏｔｅｃｈ． Ｂｉｏｃｈｅｍ． Ｖｏｌ．６０ Ｎｏ．１２, 1996, ｐｐ．２０２３-２０２７
JPN6012001696; 日本臨床生理学会雑誌 Ｖｏｌ．３０ 臨時増刊号, 200010, ｐ．６１
JPN6012001699; 糖尿病 Ｖｏｌ．４２ Ｎｏ．２, 1999, ｐｐ．１２７-１３０
JPN6012059245; Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ ＡＮ ２００５：２０８５９６
JPN6012059247; Ｊ． Ｐｈａｒｍ． Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．４７, 1995, ｐｐ．１３８-１４２
JPN6012059249; Ｂｉｏｃｈｅｍ． Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．６１, 2001, ｐｐ．１５５-１６４
Attorney, Agent or Firm:
Kaoru Watanabe