Title:
体重のモジュレーター、対応する核酸およびタンパク質、ならびにそれらの診断および治療用途
Document Type and Number:
Japanese Patent JP3985007
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new labeled nucleic acid molecule comprising an obesity polypeptide containing a specific amino acid sequence and capable of controlling animal body weight and enabling fat accumulation control of mammal and hybridizing with DNA coding for a body weight modulator. SOLUTION: This nucleic acid molecule comprises an obesity(OB) polypeptide containing an amino acid sequence represented by formulae I, II, etc., and capable of controlling body weight in animals or allele variant or analog containing its fragment and having body weight controlling activity, in which one or more amino acid residues are lost, replaced or inserted, or detectable labeled new nucleic molecule capable of hybridizing with isolated DNA molecule coding for immunogenic fragment of OB polypeptide and hybridizes with a body weight modulator gene enabling control of fat accumulation and fat content and is useful for diagnosis and treatment of obesity, etc.
Inventors:
Jeffrey M. Friedman
Yin Zhang
Ricard Pro Enca
Margarita Maffei
Jeffrey El. Harras
Ketan Kajiwara
Stephen Kay. Burley
Yin Zhang
Ricard Pro Enca
Margarita Maffei
Jeffrey El. Harras
Ketan Kajiwara
Stephen Kay. Burley
Application Number:
JP2005376732A
Publication Date:
October 03, 2007
Filing Date:
December 27, 2005
Export Citation:
Assignee:
THE ROCKEFELLER UNIVERSITY
International Classes:
A61K38/00; G01N33/53; A61K31/70; A61K31/711; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P3/04; A61P3/06; A61P3/10; A61P9/12; C07H21/04; C07K7/08; C07K14/47; C07K16/18; C12N1/19; C12N1/21; C12N5/00; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/68; C12R1/07; C12R1/19; C12R1/38; C12R1/465; C12R1/72; C12R1/84; C12R1/85; C12R1/91
Other References:
Nature, Vol.372(6505), pp.425-432 (Dec 1, 1994)
Attorney, Agent or Firm:
Hidesaku Yamamoto