Title:
転写因子の遺伝子導入による骨・軟骨組織再生方法
Document Type and Number:
Japanese Patent JP4921692
Kind Code:
B2
Abstract:
This invention provides a method of rapid and adequate culture of cells isolated from a body to effectively construct bone/cartilage tissues and implants containing the bone/cartilage tissues constructed by the aforementioned method. In this method, osteo-/chondro-inducible transcription factor genes are transfected into bone-marrow-derived cells isolated from a body using an adenoviral or a retroviral vector to grow on adequate scaffolds. The constructed bone/cartilage tissues are transplanted into a body together with the scaffolds. Thus, they can be used as substitutional bone/cartilage implants.
Inventors:
Uemura Tokiko
Tetsuya Tateishi
Hiroko Kojima
Tetsuya Tateishi
Hiroko Kojima
Application Number:
JP2003516573A
Publication Date:
April 25, 2012
Filing Date:
July 03, 2002
Export Citation:
Assignee:
National Institute of Advanced Industrial Science and Technology
Japan Science and Technology Agency
Japan Science and Technology Agency
International Classes:
A61L27/00; A61F2/28; A61L27/10; A61L27/18; A61L27/24; A61L27/26; A61L27/38; A61L27/42; A61L27/44; A61L27/48; A61L27/56; A61L27/58; A61P19/00; C12N5/077; C12N5/0775; A61K35/12; A61K48/00
Domestic Patent References:
| JPH10194987A | 1998-07-28 |
Foreign References:
| US6077987A | 2000-06-20 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Satoshi Fujita