Title:
骨形成及び抗脂肪細胞形成オキシステロール類
Document Type and Number:
Japanese Patent JP2009512422
Kind Code:
A
Abstract:
The present invention discloses osteogenic and anti-adipogenic oxysterols. Agents and methods for protecting, blocking or rescuing marrow stromal cells from the inhibitory effects of oxidative stress on their osteoblastic cellular differentiation are disclosed. Exemplary agents include oxysterols alone or in synergistic combinations, as well as hedgehog or Wnt signaling activators. The synergistic effects of oxysterols and bone morphogenic proteins are also disclosed.
Inventors:
Parami Farad
Application Number:
JP2008529347A
Publication Date:
March 26, 2009
Filing Date:
September 05, 2006
Export Citation:
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
International Classes:
A61K31/575; A61K31/58; A61K35/12; A61K38/22; A61P19/08; A61P19/10; C12N5/077; C07J9/00; C07J17/00; C12N15/09
Foreign References:
| WO2005020928A2 | 2005-03-10 | |||
| WO2004019884A2 | 2004-03-11 |
Attorney, Agent or Firm:
Masaki Hirota